Kenneth Mackie

Kenneth Mackie

Director, Gill Center Professor

Professor, Psychological and Brain Sciences

  • (812) 855-2042
  • Multidisciplinary Science Building II 120
  • Office Hours


  • M.D., Yale University, 1984
  • ScB, Engineering, Brown University, 1980


The Mackie lab examines the role and function of the endocannabinoid system by using a combination of electrophysiological, imaging, biochemical and immunological approaches. The endocannabinoid system is comprised of cannabinoid receptors, endogenous cannabinoids (endocannabinoids), and the enzymes that regulate the production and degradation of endocannabinoids. ?9THC, the principal psychoactive component of cannabis, interacts with this system to produce the classic effects of cannabis intoxication. In addition, this system is widely involved in multiple physiologically important processes including memory, motivation, movement, analgesia, and emesis. Through our studies, we hope to better understand the implications of social and therapeutic use of drugs that influence this fascinating system.