Anne L.  Prieto

Anne L. Prieto

Associate Professor, Psychological and Brain Sciences

  • (812) 855-4642
  • Multidisciplinary Science Building II 222
  • Office Hours
    By Appointment Only


  • Ph.D., Rockefeller University, 1992
  • Licentiate, Pontificia Universidad Catolica de Chile, 1985


The research in my laboratory focuses on understanding the signaling mechanisms that underlie the establishment and maintenance of mature neuronal phenotypes in the developing brain. In particular, we investigate the potential functional roles of receptor protein tyrosine kinases (RPTKs) and their ligands in the central nervous system. Currently, we study a novel RPTK family, the Axl subfamily, which includes at least 4 members, Tyro-3, Axl, Mer and Rek. They share a common ligand, the molecule Gas6 (for growth-arrest specific gene-6) capable of inducing receptor phosphorylation and thus initiating intracellular signaling events upon binding. Our current efforts are focused on possible roles for these receptors and their cognate ligand in promoting the survival or growth of subsets of neural cells, in mediating cell adhesion, and in modifying synaptic function and plasticity.