About

Research in my laboratory focuses on the neural mechanisms underlying basic behavioral processes such as habit learning, motor control, and motivation. We are especially interested in cortical interactions with the basal ganglia and related limbic nuclei. Dysfunctional cortical-subcortical circuitry is central to the development of drug craving, plays a critical role in the signs and symptoms of several neurological diseases, and may contribute to motor deficits with aging. To assess how these brain systems operate and interact under freely behaving conditions, we combine electrophysiological approaches (single-unit recording and local field potentials) with recent analytical innovations (coherence assessment and causality detection). We also use electrochemical (slow- and fast-scan cyclic voltammetry) techniques along with genomic and proteomic analyses to measure neurotransmitter function at the neuronal level during behavior.

A primary area of interest is the change in neuronal information processing induced by cocaine and other psychomotor stimulants. We have a long-standing program aimed at investigating the role of dopamine and its interaction with glutamate in addiction and relapse. Another primary area of interest is the neural network dysfunction underlying Huntington’s disease, an autosomal dominant and fatal neurodegenerative condition. In both of these areas of interest, we are developing therapeutic targets centered on the clearance of glutamate from forebrain extracellular fluid.

Further information on our research programs are available at: www.indiana.edu/~basalgan/